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Plakophilin3 Loss Leads to an Increase in PRL3 Levels Promoting K8 Dephosphorylation, Which Is Required for Transformation and Metastasis
The desmosome anchors keratin filaments in epithelial cells leading to the formation of a tissue wide IF network. Loss of the desmosomal plaque protein plakophilin3 (PKP3) in HCT116 cells, leads to an increase in neoplastic progression and metastasis, which was accompanied by an increase in K8 level...
Autores principales: | Khapare, Nileema, Kundu, Samrat T., Sehgal, Lalit, Sawant, Mugdha, Priya, Rashmi, Gosavi, Prajakta, Gupta, Neha, Alam, Hunain, Karkhanis, Madhura, Naik, Nishigandha, Vaidya, Milind M., Dalal, Sorab N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368841/ https://www.ncbi.nlm.nih.gov/pubmed/22701666 http://dx.doi.org/10.1371/journal.pone.0038561 |
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