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A Novel Antibody Humanization Method Based on Epitopes Scanning and Molecular Dynamics Simulation
1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and delivers antigen to dendritic cells (DCs). The potentially clinical application of this antibody is limited by its murine origin. Traditional humanization method such as complementarity determining regions (CDRs)...
Autores principales: | Zhang, Ding, Chen, Cai-Feng, Zhao, Bin-Bin, Gong, Lu-Lu, Jin, Wen-Jing, Liu, Jing-Jun, Wang, Jing-Fei, Wang, Tian-Tian, Yuan, Xiao-Hui, He, You-Wen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836750/ https://www.ncbi.nlm.nih.gov/pubmed/24278299 http://dx.doi.org/10.1371/journal.pone.0080636 |
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