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ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling
OBJECTIVE: Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem cell-like properties and their role in platinum resistance. METHODS: Isogenic ovarian cancer cell lines for platinum sensitivity (A2780) a...
Autores principales: | Meng, Erhong, Mitra, Aparna, Tripathi, Kaushlendra, Finan, Michael A., Scalici, Jennifer, McClellan, Steve, da Silva, Luciana Madeira, Reed, Eddie, Shevde, Lalita A., Palle, Komaraiah, Rocconi, Rodney P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162571/ https://www.ncbi.nlm.nih.gov/pubmed/25216266 http://dx.doi.org/10.1371/journal.pone.0107142 |
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