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Single point mutation in adeno-associated viral vectors -DJ capsid leads to improvement for gene delivery in vivo
BACKGROUND: Rational design of AAV capsids is a simple method for enhancing AAV transduction efficiency. AAV-DJ is a highly recombinogenic hybrid vector created from DNA shuffling of eight AAV serotypes, which mediates efficient gene expression both in vitro and in vivo. AAV2 and AAV8 are the closes...
Autores principales: | Mao, Yingying, Wang, Xuejun, Yan, Renhe, Hu, Wei, Li, Andrew, Wang, Shengqi, Li, Hongwei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700607/ https://www.ncbi.nlm.nih.gov/pubmed/26729248 http://dx.doi.org/10.1186/s12896-015-0230-0 |
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