Optimal design of gene knockout experiments for gene regulatory network inference

Motivation: We addressed the problem of inferring gene regulatory network (GRN) from gene expression data of knockout (KO) experiments. This inference is known to be underdetermined and the GRN is not identifiable from data. Past studies have shown that suboptimal design of experiments (DOE) contrib...

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Detalles Bibliográficos
Autores principales: Ud-Dean, S. M. Minhaz, Gunawan, Rudiyanto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803391/
https://www.ncbi.nlm.nih.gov/pubmed/26568633
http://dx.doi.org/10.1093/bioinformatics/btv672

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