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Accumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease
Mitochondrial dysfunction is associated with familial Alzheimer’s disease (fAD), and the accumulation of damaged mitochondria has been reported as an initial symptom that further contributes to disease progression. In the amyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by β-sec...
Autores principales: | Lee, Seung-Eun, Kwon, Daekee, Shin, Nari, Kong, Dasom, Kim, Nam Gyo, Kim, Hee-Yeong, Kim, Min-Ji, Choi, Soon Won, Kang, Kyung-Sun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748980/ https://www.ncbi.nlm.nih.gov/pubmed/35013145 http://dx.doi.org/10.1038/s41420-021-00796-3 |
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