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How location and cellular signaling combine to activate the NLRP3 inflammasome

NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon detection of an activating stimulus, NLRP3 transitions from an inactive homo-oligomeric multimer into an active multimeric inflammas...

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Detalles Bibliográficos
Autores principales:	Akbal, Anil, Dernst, Alesja, Lovotti, Marta, Mangan, Matthew S. J., McManus, Róisín M., Latz, Eicke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622870/ https://www.ncbi.nlm.nih.gov/pubmed/36127465 http://dx.doi.org/10.1038/s41423-022-00922-w

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