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Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2

Variants of isocitrate dehydrogenase (IDH) 1 and 2 (IDH1/2) alter metabolism in cancer cells by catalyzing the NADPH-dependent reduction of 2-oxoglutarate (2OG) to (2R)-hydroxyglutarate. However, it is unclear how derivatives of 2OG can affect cancer cell metabolism. Here, we used synthetic C3- and...

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Detalles Bibliográficos
Autores principales:	Liu, Xiao, Reinbold, Raphael, Liu, Shuang, Herold, Ryan A., Rabe, Patrick, Duclos, Stéphanie, Yadav, Rahul B., Abboud, Martine I., Thieffine, Sandrine, Armstrong, Fraser A., Brewitz, Lennart, Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939733/ https://www.ncbi.nlm.nih.gov/pubmed/36621625 http://dx.doi.org/10.1016/j.jbc.2023.102873

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