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Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity
Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knock...
Autores principales: | Rodriguez-Zabala, Maria, Ramakrishnan, Ramprasad, Reinbach, Katrin, Ghosh, Somadri, Oburoglu, Leal, Falqués-Costa, Antoni, Bellamkonda, Kishan, Ehinger, Mats, Peña-Martínez, Pablo, Puente-Moncada, Noelia, Lilljebjörn, Henrik, Cammenga, Jörg, Pronk, Cornelis Jan, Lazarevic, Vladimir, Fioretos, Thoas, Hagström-Andersson, Anna K., Woods, Niels-Bjarne, Järås, Marcus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Hematology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509671/ https://www.ncbi.nlm.nih.gov/pubmed/37505194 http://dx.doi.org/10.1182/bloodadvances.2023009967 |
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