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Intrinsic Determinants of Aβ (12–24) pH-Dependent Self-Assembly Revealed by Combined Computational and Experimental Studies
The propensity of amyloid-[Image: see text] (A[Image: see text]) peptide to self-assemble into highly ordered amyloid structures lies at the core of their accumulation in the brain during Alzheimer's disease. By using all-atom explicit solvent replica exchange molecular dynamics simulations, we...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177821/ https://www.ncbi.nlm.nih.gov/pubmed/21957446 http://dx.doi.org/10.1371/journal.pone.0024329 |