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Proteomic Identification of IPSE/alpha-1 as a Major Hepatotoxin Secreted by Schistosoma mansoni Eggs
BACKGROUND: Eggs deposited in the liver of the mammalian host by the blood fluke parasite, Schistosoma mansoni, normally drive a T-helper-2 (Th2)-mediated granulomatous response in immune-competent mice. By contrast, in mice deprived of T-cells and incapable of producing granulomata, egg-secreted pr...
Autores principales: | Abdulla, Maha-Hamadien, Lim, Kee-Chong, McKerrow, James H., Caffrey, Conor R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201919/ https://www.ncbi.nlm.nih.gov/pubmed/22039561 http://dx.doi.org/10.1371/journal.pntd.0001368 |
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