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Efficient discovery of anti-inflammatory small molecule combinations using evolutionary computing
The control of biochemical fluxes is distributed and to perturb complex intracellular networks effectively it is often necessary to modulate several steps simultaneously. However, the number of possible permutations leads to a combinatorial explosion in the number of experiments that would have to b...
Autores principales: | Small, Ben G, McColl, Barry W, Allmendinger, Richard, Pahle, Jürgen, López-Castejón, Gloria, Rothwell, Nancy J, Knowles, Joshua, Mendes, Pedro, Brough, David, Kell, Douglas B |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223407/ https://www.ncbi.nlm.nih.gov/pubmed/22020553 http://dx.doi.org/10.1038/nchembio.689 |
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