Cargando…
Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation
Hypoxia-inducible factor 1 (HIF-1), the major transcription factor specifically activated during hypoxia, regulates genes involved in critical aspects of cancer biology, including angiogenesis, cell proliferation, glycolysis and invasion. The HIF-1a subunit is stabilized by low oxygen, genetic alter...
Autores principales: | Sheffer, Michal, Simon, Amos J., Jacob-Hirsch, Jasmine, Rechavi, Gideon, Domany, Eytan, Givol, David, D’Orazi, Gabriella |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282077/ https://www.ncbi.nlm.nih.gov/pubmed/22202117 |
Ejemplares similares
-
Targeting Hypoxia in Cancer Cells by Restoring Homeodomain Interacting Protein-Kinase 2 and p53 Activity and Suppressing HIF-1α
por: Nardinocchi, Lavinia, et al.
Publicado: (2009) -
p53 reactivation: The link to zinc
por: D’Orazi, Gabriella, et al.
Publicado: (2012) -
HIPK2 modulates p53 activity towards pro-apoptotic transcription
por: Puca, Rosa, et al.
Publicado: (2009) -
Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo
por: Nardinocchi, Lavinia, et al.
Publicado: (2010) -
Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells
por: Cirone, Mara, et al.
Publicado: (2013)