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Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model
BACKGROUND: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases. One solution for overcoming this barrier is a transport by binding of these drugs to surface-modified nanoparticles. Especially apolipoprotei...
Autores principales: | Wagner, Sylvia, Zensi, Anja, Wien, Sascha L., Tschickardt, Sabrina E., Maier, Wladislaw, Vogel, Tikva, Worek, Franz, Pietrzik, Claus U., Kreuter, Jörg, von Briesen, Hagen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291552/ https://www.ncbi.nlm.nih.gov/pubmed/22396775 http://dx.doi.org/10.1371/journal.pone.0032568 |
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