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Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria
A proline-to-serine substitution at position 56 in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB; VAPBP56S) causes some dominantly inherited familial forms of motor neuron disease, including amyotrophic lateral sclerosis (ALS) type-8. Here, we show that expression...
Autores principales: | Mórotz, Gábor M., De Vos, Kurt J., Vagnoni, Alessio, Ackerley, Steven, Shaw, Christopher E., Miller, Christopher C.J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315205/ https://www.ncbi.nlm.nih.gov/pubmed/22258555 http://dx.doi.org/10.1093/hmg/dds011 |
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