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SubcloneSeeker: a computational framework for reconstructing tumor clone structure for cancer variant interpretation and prioritization
Many tumors are composed of genetically divergent cell subpopulations. We report SubcloneSeeker, a package capable of exhaustive identification of subclone structures and evolutionary histories with bulk somatic variant allele frequency measurements from tumor biopsies. We present a statistical fram...
Autores principales: | Qiao, Yi, Quinlan, Aaron R, Jazaeri, Amir A, Verhaak, Roeland GW, Wheeler, David A, Marth, Gabor T |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180956/ https://www.ncbi.nlm.nih.gov/pubmed/25160522 http://dx.doi.org/10.1186/s13059-014-0443-x |
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