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A Leak Pathway for Luminal Protons in Endosomes Drives Oncogenic Signaling in Glioblastoma
Epidermal growth factor receptor (EGFR) signaling is a potent driver of glioblastoma, a malignant and lethal form of brain cancer. Disappointingly, inhibitors targeting receptor tyrosine kinase activity are not clinically effective, and EGFR persists on the plasma membrane to maintain tumor growth a...
Autores principales: | Kondapalli, Kalyan C., Llongueras, Jose P., Capilla-González, Vivian, Prasad, Hari, Hack, Anniesha, Smith, Christopher, Guerrero-Cázares, Hugo, Quiñones-Hinojosa, Alfredo, Rao, Rajini |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354686/ https://www.ncbi.nlm.nih.gov/pubmed/25662504 http://dx.doi.org/10.1038/ncomms7289 |
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