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Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease
While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged. Using deep sequencing, we analyzed a unique collection of longitudinal viral samples from 93 patients who have been treated with therapi...
Autores principales: | Flynn, William F., Chang, Max W., Tan, Zhiqiang, Oliveira, Glenn, Yuan, Jinyun, Okulicz, Jason F., Torbett, Bruce E., Levy, Ronald M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404092/ https://www.ncbi.nlm.nih.gov/pubmed/25894830 http://dx.doi.org/10.1371/journal.pcbi.1004249 |
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