Tackling amyloidogenesis in Alzheimer’s disease with A2V variants of Amyloid-β

We developed a novel therapeutic strategy for Alzheimer’s disease (AD) exploiting the properties of a natural variant of Amyloid-β (Aβ) carrying the A2V substitution, which protects heterozygous carriers from AD by its ability to interact with wild-type Aβ, hindering conformational changes and assem...

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Detalles Bibliográficos
Autores principales: Di Fede, Giuseppe, Catania, Marcella, Maderna, Emanuela, Morbin, Michela, Moda, Fabio, Colombo, Laura, Rossi, Alessandro, Cagnotto, Alfredo, Virgilio, Tommaso, Palamara, Luisa, Ruggerone, Margherita, Giaccone, Giorgio, Campagnani, Ilaria, Costanza, Massimo, Pedotti, Rosetta, Salvalaglio, Matteo, Salmona, Mario, Tagliavini, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750079/
https://www.ncbi.nlm.nih.gov/pubmed/26864599
http://dx.doi.org/10.1038/srep20949

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