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Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor

Although respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants and young children, attempts to develop an effective therapy have so far proved unsuccessful. Here we report the preclinical profiles of PC786, a potent nonnucleoside RSV L protein pol...

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Detalles Bibliográficos
Autores principales:	Coates, Matthew, Brookes, Daniel, Kim, Young-In, Allen, Heather, Fordyce, Euan A. F., Meals, Elizabeth A., Colley, Thomas, Ciana, Claire-Lise, Parra, Guillaume F., Sherbukhin, Vladimir, Stockwell, Jennifer A., Thomas, Jennifer C., Hunt, S. Fraser, Anderson-Dring, Lauren, Onions, Stuart T., Cass, Lindsey, Murray, Peter J., Ito, Kazuhiro, Strong, Pete, DeVincenzo, John P., Rapeport, Garth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571287/ https://www.ncbi.nlm.nih.gov/pubmed/28652242 http://dx.doi.org/10.1128/AAC.00737-17

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