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TLR3 agonism re‐establishes CNS immune competence during α4‐integrin deficiency
OBJECTIVE: Natalizumab blocks α4‐integrin‐mediated leukocyte migration into the central nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a high risk of progressive multifocal encephalopathy (PML), an opportunistic infection with JV virus that may be prompt...
Autores principales: | Hussain, Rehana Z., Cravens, Petra C., Doelger, Richard, Dentel, Brianne, Herndon, Emily, Loof, Nicolas, Tsai, Peter, Okuda, Darin T., Racke, Michael K., Stüve, Olaf |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292184/ https://www.ncbi.nlm.nih.gov/pubmed/30564621 http://dx.doi.org/10.1002/acn3.664 |
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