Cargando…

Preclinical Development of Crocus sativus-Based Botanical Lead IIIM-141 for Alzheimer’s Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology

[Image: see text] Crocus sativus L. (family: Iridaceae) has been documented in traditional medicine with numerous medicinal properties. Recently, we have shown that C. sativus extract (IIIM-141) displays promising efficacy in a genetic mice (5XFAD) model of Alzheimer’s disease (AD) (ACS Chem. Neuros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bharate, Sonali S., Kumar, Vikas, Singh, Gurdarshan, Singh, Amarinder, Gupta, Mehak, Singh, Deepika, Kumar, Ajay, Vishwakarma, Ram A., Bharate, Sandip B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644748/ https://www.ncbi.nlm.nih.gov/pubmed/31459089 http://dx.doi.org/10.1021/acsomega.8b00841

Ejemplares similares

Selection of a Water-Soluble Salt Form of a Preclinical Candidate, IIIM-290: Multiwell-Plate Salt Screening and Characterization
por: Kumar, Vikas, et al.
Publicado: (2018)

IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy
por: Ali, Mehboob, et al.
Publicado: (2021)

Quantitative Determination and Characterization of a Kashmir Saffron (Crocus sativus L.)-Based Botanical Supplement Using Single-Laboratory Validation Study by HPLC-PDA with LC–MS/MS and HPTLC Investigations
por: Girme, Aboli, et al.
Publicado: (2021)

Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols
por: Katoch, Meenu, et al.
Publicado: (2019)

Saffron (Crocus sativus L.): As an Antidepressant
por: Siddiqui, Mohammad J., et al.
Publicado: (2018)

Selective Th2 Upregulation by Crocus sativus: A Neutraceutical Spice
por: Bani, Sarang, et al.
Publicado: (2011)

Comprehensive transcriptome analysis of Crocus sativus for discovery and expression of genes involved in apocarotenoid biosynthesis
por: Baba, Shoib Ahmad, et al.
Publicado: (2015)

The Relation between Drying Conditions and the Development of Volatile Compounds in Saffron (Crocus sativus)
por: Cid-Pérez, Teresa Soledad, et al.
Publicado: (2021)

Crocus sativus L.: A comprehensive review
por: Srivastava, R., et al.
Publicado: (2010)

Botany, Taxonomy and Cytology of Crocus sativus series
por: Saxena, R. B.
Publicado: (2010)

Estimating thermodynamic equilibrium solubility and solute–solvent interactions of niclosamide in eight mono-solvents at different temperatures
por: Bhanushali, Jigar S., et al.
Publicado: (2022)

AFLP and MS-AFLP Analysis of the Variation within Saffron Crocus (Crocus sativus L.) Germplasm
por: Busconi, Matteo, et al.
Publicado: (2015)

Epigenetic Variability Among Saffron Crocus (Crocus sativus L.) Accessions Characterized by Different Phenotypes
por: Busconi, Matteo, et al.
Publicado: (2021)

Discovery of Pongol, the Furanoflavonoid, as an Inhibitor of CDK7/Cyclin H/MAT1 and Its Preliminary Structure–Activity Relationship
por: Bhurta, Deendyal, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Coumarin Triazoles as Dual Inhibitors of Cholinesterases and β-Secretase
por: Sharma, Ankita, et al.
Publicado: (2023)

Comparative Metagenomics Reveal Phylum Level Temporal and Spatial Changes in Mycobiome of Belowground Parts of Crocus sativus
por: Ambardar, Sheetal, et al.
Publicado: (2016)

Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients
por: Samarghandian, Saeed, et al.
Publicado: (2014)

Razi’s Al-Hawi and saffron (Crocus sativus): a review
por: Mollazadeh, Hamid, et al.
Publicado: (2015)

Bioactivity and Bioavailability of the Major Metabolites of Crocus sativus L. Flower
por: Moratalla-López, Natalia, et al.
Publicado: (2019)

Transcriptome profiling of the flowering transition in saffron (Crocus sativus L.)
por: Hu, Jing, et al.
Publicado: (2020)

Therapeutic Potential of Saffron (Crocus sativus L.) in Ischemia Stroke
por: Azami, Shakiba, et al.
Publicado: (2021)

Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts
por: Mykhailenko, Olha, et al.
Publicado: (2021)

Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis
por: Munirah, Mohd Puad, et al.
Publicado: (2022)

A novel quinazolinone derivative induces cytochrome c interdependent apoptosis and autophagy in human leukemia MOLT-4 cells
por: Kumar, Suresh, et al.
Publicado: (2014)

Cloning, Structural Characterization, and Phylogenetic Analysis of Flower MADS-Box Genes from Crocus (Crocus sativus L.)
por: Tsaftaris, Athanasios S., et al.
Publicado: (2007)

Crocus sativus L. (saffron) for cancer chemoprevention: A mini review
por: Bhandari, Prasan R.
Publicado: (2015)

Could Crocus sativus (saffron) be combined with conventional therapies for ocular diseases?
por: Bhandari, Prasan R
Publicado: (2015)

The Effect of the Crocus Sativus L. Carotenoid, Crocin, on the Polymerization of Microtubules, in Vitro
por: Zarei Jaliani, Hossein, et al.
Publicado: (2013)

Hormone and Microorganism Treatments in the Cultivation of Saffron (Crocus Sativus L.) Plants
por: Aytekin, Alper, et al.
Publicado: (2008)

Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract
por: Almodóvar, Paula, et al.
Publicado: (2020)

Insights from the analysis of draft genome sequence of Crocus sativus L.
por: Ambardar, Sheetal, et al.
Publicado: (2022)

Rhizosphere microorganisms of Crocus sativus as antagonists against pathogenic Fusarium oxysporum
por: Zhang, Jiahao, et al.
Publicado: (2022)

Flavonoid Composition and Antibacterial Properties of Crocus sativus L. Petal Extracts
por: Naim, Nadia, et al.
Publicado: (2022)

Injury and not the pathogen is the primary cause of corm rot in Crocus sativus (saffron)
por: Mansotra, Ritika, et al.
Publicado: (2023)

Introduction of high-value Crocus sativus (saffron) cultivation in non-traditional regions of India through ecological modelling
por: Kumar, Amit, et al.
Publicado: (2022)

Effects of Saffron (Crocus sativus L.) Aqueous Extract on In vitro Maturation, Fertilization and Embryo Development of Mouse Oocytes
por: Tavana, Somayeh, et al.
Publicado: (2012)

Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria
por: Singh, Samsher, et al.
Publicado: (2017)

Development of a system for efficient callus production, somatic embryogenesis and gene editing using CRISPR/Cas9 in Saffron (Crocus sativus L.)
por: Chib, Sudha, et al.
Publicado: (2020)

Determination of Metal Content in Crocus sativus L. Corms in Dormancy and Waking Stages
por: Esmaeili, Nardana, et al.
Publicado: (2013)

Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment
por: Naghibi, Sayede Maryam, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7hjqf0b7qdn2daacpmb6tkunbk