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A narrative review of estimands in drug development and regulatory evaluation: old wine in new barrels?
BACKGROUND: An estimand defines the target of estimation for a clinical trial through specification of the treatment, target population, variable, population-level summary and of the strategies for intercurrent events. A carefully defined estimand aligns the clinical trial design and analysis with t...
Autores principales: | Mitroiu, M., Oude Rengerink, K., Teerenstra, S., Pétavy, F., Roes, K. C. B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376663/ https://www.ncbi.nlm.nih.gov/pubmed/32703247 http://dx.doi.org/10.1186/s13063-020-04546-1 |
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