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Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype in pulmonary arterial hypertension (PAH). BMP9 is shown to reinstate BMP receptor type-II (BMPR2) levels and thereby mitig...
Autores principales: | Szulcek, Robert, Sanchez-Duffhues, Gonzalo, Rol, Nina, Pan, Xiaoke, Tsonaka, Roula, Dickhoff, Chris, Yung, Lai Ming, Manz, Xue D., Kurakula, Kondababu, Kiełbasa, Szymon M., Mei, Hailiang, Timens, Wim, Yu, Paul B., Bogaard, Harm-Jan, Goumans, Marie-José |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524846/ https://www.ncbi.nlm.nih.gov/pubmed/32813135 http://dx.doi.org/10.1007/s10456-020-09741-x |
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