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SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons
Modulation of the neuronal K(+)/Cl(−) cotransporter 2 (KCC2) activity, which mediates Cl(−) export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an essential component of membrane insertion machinery. Usi...
Autores principales: | Asraf, Hila, Bogdanovic, Milos, Gottesman, Noa, Sekler, Israel, Aizenman, Elias, Hershfinkel, Michal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800107/ https://www.ncbi.nlm.nih.gov/pubmed/35118363 http://dx.doi.org/10.1016/j.isci.2022.103751 |
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