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A new method to detect loss of heterozygosity using cohort heterozygosity comparisons
BACKGROUND: Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA samples. However, for many archival sam...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885361/ https://www.ncbi.nlm.nih.gov/pubmed/20462409 http://dx.doi.org/10.1186/1471-2407-10-195 |