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Accurate single nucleotide variant detection in viral populations by combining probabilistic clustering with a statistical test of strand bias
BACKGROUND: Deep sequencing is a powerful tool for assessing viral genetic diversity. Such experiments harness the high coverage afforded by next generation sequencing protocols by treating sequencing reads as a population sample. Distinguishing true single nucleotide variants (SNVs) from sequencing...
Autores principales: | McElroy, Kerensa, Zagordi, Osvaldo, Bull, Rowena, Luciani, Fabio, Beerenwinkel, Niko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848937/ https://www.ncbi.nlm.nih.gov/pubmed/23879730 http://dx.doi.org/10.1186/1471-2164-14-501 |
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