HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO(2) Production and Neurotoxic Activity

BACKGROUND: The potential role of the human immunodeficiency virus-1 (HIV-1) accessory protein Nef in the pathogenesis of neuroAIDS is still poorly understood. Nef is a molecular adapter that influences several cellular signal transduction events and membrane trafficking. In human macrophages, Nef e...

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Detalles Bibliográficos
Autores principales: Mangino, Giorgio, Famiglietti, Marylinda, Capone, Caterina, Veroni, Caterina, Percario, Zulema Antonia, Leone, Stefano, Fiorucci, Gianna, Lülf, Sebastian, Romeo, Giovanna, Agresti, Cristina, Persichini, Tiziana, Geyer, Matthias, Affabris, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465743/
https://www.ncbi.nlm.nih.gov/pubmed/26066624
http://dx.doi.org/10.1371/journal.pone.0130189

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