Cargando…

Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors

OBJECTIVE: Alcoholic steatohepatitis is a life-threatening condition with short-term mortality up to 40%. It features hepatic neutrophil infiltration and blood neutrophilia, and may evolve from ethanol-induced breakdown of the enteric barrier and consequent bacteraemia. Signalling through CXCR1/2 G-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wieser, Verena, Adolph, Timon E, Enrich, Barbara, Kuliopulos, Athan, Kaser, Arthur, Tilg, Herbert, Kaneider, Nicole C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531226/ https://www.ncbi.nlm.nih.gov/pubmed/26858343 http://dx.doi.org/10.1136/gutjnl-2015-310344

Ejemplares similares

Protease-Activated Receptor 1 as Therapeutic Target in Breast, Lung, and Ovarian Cancer: Pepducin Approach
por: Covic, Lidija, et al.
Publicado: (2018)

Liver stiffness by transient elastography accompanies illness severity in COVID-19
por: Effenberger, Maria, et al.
Publicado: (2020)

Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial
por: Thomas, Martin Geoffrey, et al.
Publicado: (2019)

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis
por: Angelini, Giulia, et al.
Publicado: (2023)

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis
por: Koh, Eun Hee, et al.
Publicado: (2021)

Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
por: Conche, Claire, et al.
Publicado: (2023)

Reliability and validity of the Chronic Liver Disease Questionnaire (CLDQ) in adults with non-alcoholic steatohepatitis (NASH)
por: Chawla, Kashmira S, et al.
Publicado: (2016)

Relationship between Streptococcus mutans expressing Cnm in the oral cavity and non-alcoholic steatohepatitis: a pilot study
por: Tonomura, Shuichi, et al.
Publicado: (2019)

Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance
por: Sun, Nannan, et al.
Publicado: (2021)

Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression
por: Loyer, Xavier, et al.
Publicado: (2016)

PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study
por: Kuliopulos, Athan, et al.
Publicado: (2020)

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
por: Xiong, Zhewen, et al.
Publicado: (2023)

PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
por: Lu, Li-Gong, et al.
Publicado: (2022)

GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity
por: Ruffolo, Luis I, et al.
Publicado: (2022)

Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker
por: Baselli, Guido Alessandro, et al.
Publicado: (2020)

Thyroid Hormones and Thyromimetics: A New Approach to Nonalcoholic Steatohepatitis?
por: Sinha, Rohit A., et al.
Publicado: (2020)

Weight Loss Induced by Bariatric Surgery Restricts Hepatic GDF15 Expression
por: Adolph, Timon E., et al.
Publicado: (2018)

EP1272: DIETARY LIPIDS FUEL METABOLIC ENTERITIS IN CROHN'S DISEASE
por: Schwärzler, Julian, et al.
Publicado: (2022)

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
por: Ikenaga, Naoki, et al.
Publicado: (2017)

Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease
por: Kuttkat, Nadine, et al.
Publicado: (2017)

Nonalcoholic steatohepatitis diagnosis and treatment from the perspective of patients and primary care physicians: a cross-sectional survey
por: Nadolsky, Karl, et al.
Publicado: (2023)

A comparative study on roles of natural killer T cells in two diet-induced non-alcoholic steatohepatitis-related fibrosis in mice
por: Zheng, Shumei, et al.
Publicado: (2022)

Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial
por: Armstrong, Matthew J, et al.
Publicado: (2013)

Apoptosis and diagnosis of nonalcoholic steatohepatitis
por: Kim, Chang Wook, et al.
Publicado: (2011)

Multiple Parallel Hits Hypothesis in Nonalcoholic Fatty Liver Disease: Revisited After a Decade
por: Tilg, Herbert, et al.
Publicado: (2021)

Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome
por: Asfari, Mohammad Maysara, et al.
Publicado: (2020)

Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions
por: Adolph, Timon E., et al.
Publicado: (2017)

Antagonizing S1P(3) Receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis
por: Corvino, Angela, et al.
Publicado: (2021)

Neurodegeneration in Hepatic and Neurologic Wilson’s Disease
por: Viveiros, André, et al.
Publicado: (2021)

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury
por: Zhuang, Yuan, et al.
Publicado: (2020)

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis
por: Tressel, Sarah L, et al.
Publicado: (2011)

Dietary Factors: Major Regulators of the Gut's Microbiota
por: Moschen, Alexander R., et al.
Publicado: (2012)

Role of Helicobacter pylori and interleukin 6 -174 gene polymorphism in dyslipidemia: a case–control study
por: Pohjanen, Vesa-Matti, et al.
Publicado: (2016)

Gut Dysfunction and Non-alcoholic Fatty Liver Disease
por: Grabherr, Felix, et al.
Publicado: (2019)

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
por: Grisanti, Laurel A., et al.
Publicado: (2018)

Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study
por: Amin, Neeta B, et al.
Publicado: (2022)

Calprotectin: from biomarker to biological function
por: Jukic, Almina, et al.
Publicado: (2021)

Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects
por: Kechagias, S, et al.
Publicado: (2008)

Costs and cost-effectiveness of different follow-up schedules for detection of occupational hepatitis C virus infection
por: Deuffic-Burban, S, et al.
Publicado: (2008)

Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China
por: Zhang, H W, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_fq4ngl2b5rlg2ihlceaol70mgp