Cargando…

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile

This work is a continuation of our previous research, concentrating this time on lead structure modification to increase the 5-HT(1A) receptor affinity and water solubility of designed compounds. Therefore, the compounds synthesised within the present project included structural analogues of 3β-acyl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stefanowicz, Jacek, Słowiński, Tomasz, Wróbel, Martyna Z., Ślifirski, Grzegorz, Dawidowski, Maciej, Stefanowicz, Zdzisława, Jastrzębska-Więsek, Magdalena, Partyka, Anna, Wesołowska, Anna, Turło, Jadwiga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061170/ https://www.ncbi.nlm.nih.gov/pubmed/30100693 http://dx.doi.org/10.1007/s00044-018-2203-z

Ejemplares similares

Selective 5-HT(6) Receptor Ligands (Agonist and Antagonist) Show Different Effects on Antipsychotic Drug-Induced Metabolic Dysfunctions in Rats
por: Partyka, Anna, et al.
Publicado: (2023)

Multicomponent synthesis and anticonvulsant activity of monocyclic 2,6-diketopiperazine derivatives
por: Dawidowski, Maciej, et al.
Publicado: (2013)

5-HT Receptors and the Development of New Antidepressants
por: Ślifirski, Grzegorz, et al.
Publicado: (2021)

Synthesis of New Perhydropyrrolo[1,2-a]pyrazine Derivatives and Their Evaluation in Animal Models of Epilepsy
por: Dawidowski, Maciej, et al.
Publicado: (2014)

ADN-1184, a monoaminergic ligand with 5-HT(6/7) receptor antagonist action, exhibits activity in animal models of anxiety
por: Partyka, Anna, et al.
Publicado: (2016)

Effect of 5-HT(6) Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats
por: Wesołowska, Anna, et al.
Publicado: (2021)

HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats
por: Lustyk, Klaudia, et al.
Publicado: (2022)

Model structure–activity relationship studies of potential tropane 5HT(1A), 5HT(2A), and D(2) receptor ligands
por: Słowiński, Tomasz, et al.
Publicado: (2012)

The Phenoxyalkyltriazine Antagonists for 5-HT(6) Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases
por: Sudoł, Sylwia, et al.
Publicado: (2021)

Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT(6) partial agonist in rats
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2016)

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT(6) Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
por: Latacz, Gniewomir, et al.
Publicado: (2019)

Expanding the substrate scope of ugi five-center, four-component reaction U-5C-4CR): ketones as coupling partners for secondary amino acids
por: Dawidowski, Maciej, et al.
Publicado: (2013)

Study on the effect of EMD386088, a 5-HT(6) receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2017)

Are the Hydantoin-1,3,5-triazine 5-HT(6)R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro
por: Lubelska, Annamaria, et al.
Publicado: (2019)

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT(6) Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
por: Kurczab, Rafał, et al.
Publicado: (2018)

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT(1A) and 5-HT(7) Antagonists in Animal Models
por: Pytka, Karolina, et al.
Publicado: (2015)

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT(1A) receptor partial agonists
por: Partyka, Anna, et al.
Publicado: (2020)

The Role of a School Nurse in the Care of a Child with Diabetes Mellitus Type 1 - The Perspectives of Patients and their Parents: Literature Review
por: Stefanowicz, Anna, et al.
Publicado: (2018)

Kidney Transplantation in Children with Thrombosed Inferior Caval Vein – Atypical Vascular Anastomoses
por: Szymczak, Marek, et al.
Publicado: (2019)

Identification of the Primary Structure of Selenium-Containing Polysaccharides Selectively Inhibiting T-Cell Proliferation
por: Klimaszewska, Marzenna, et al.
Publicado: (2021)

COVID-19 Pandemic—Knowledge, Attitudes, Behaviours, and Actions among Faculty of Health Sciences Students
por: Stefanowicz-Bielska, Anna, et al.
Publicado: (2021)

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT(1A) Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile
por: Sniecikowska, Joanna, et al.
Publicado: (2020)

The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2022)

Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis
por: Shelton, Catherine D., et al.
Publicado: (2021)

Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)—A Comparison Ex Vivo Study
por: Hering, Anna, et al.
Publicado: (2021)

Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)—In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase
por: Hering, Anna, et al.
Publicado: (2023)

Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification
por: Raghunadh, Akula, et al.
Publicado: (2013)

Atom-Economical Synthesis of N-Arylamides Utilizing Isopropenyl Esters with Heterogeneous Acid Catalysts
por: Ichitsuka, Tomohiro, et al.
Publicado: (2023)

Biosynthesis of Se-methyl-seleno-l-cysteine in Basidiomycetes fungus Lentinula edodes (Berk.) Pegler
por: Klimaszewska, M., et al.
Publicado: (2016)

Mangiferin Affects Melanin Synthesis by an Influence on Tyrosinase: Inhibition, Mechanism of Action and Molecular Docking Studies
por: Hering, Anna, et al.
Publicado: (2023)

Novel N-arylamide derivatives of (S)-perillic acid ((S)-PA): in vitro and in vivo cytotoxicity and antitumor evaluation
por: Mukhtar, Yusif Mohammed, et al.
Publicado: (2019)

Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities
por: Wang, Pengxu, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors
por: Ullah, Saif, et al.
Publicado: (2022)

Asenapine: an atypical antipsychotic with atypical formulations
por: Musselman, Meghan, et al.
Publicado: (2021)

Atypical antipsychotics, more than just an antipsychotic
por: Tendilla-Beltrán, Hiram, et al.
Publicado: (2020)

The comparison of the value of ct imaging and selected MRI sequences (including DWI) in the evaluation of axonal injuries
por: Paszkowska, Emilia, et al.
Publicado: (2010)

Antipsychotic, antidepressant, and cognitive-impairment properties of antipsychotics: rat profile and implications for behavioral and psychological symptoms of dementia
por: Kołaczkowski, Marcin, et al.
Publicado: (2014)

New Atypical Antipsychotics in the Treatment of Schizophrenia and Depression
por: Orzelska-Górka, Jolanta, et al.
Publicado: (2022)

Dimethylarginines in Children after Anti-Neoplastic Treatment
por: Jezierska, Michalina, et al.
Publicado: (2022)

Effect of Antipsychotic Treatment on Neutrophil-to-Lymphocyte Ratio during Hospitalization for Acute Psychosis in the Course of Schizophrenia—A Cross-Sectional Retrospective Study
por: Dawidowski, Bartosz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pqoaffop698fm7ekrq9jqmc5fg