Cargando…
Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent
In our study, we attempted to investigate the influences of P-glycoprotein (P-gp) on DL0410, a novel synthetic molecule for Alzheimer’s disease (AD) treatment, for intestinal absorption and blood-brain barrier permeability in vitro and related binding mechanisms in silico. Caco-2, MDCK, and MDCK-MDR...
Autores principales: | Pang, Xiaocong, Wang, Lin, Kang, De, Zhao, Ying, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151990/ https://www.ncbi.nlm.nih.gov/pubmed/28757552 http://dx.doi.org/10.3390/molecules22081246 |
Ejemplares similares
-
Pharmacokinetics, excretion and metabolites analysis of DL0410, a dual-acting cholinesterase inhibitor and histamine-3 receptor antagonist
por: Pang, Xiaocong, et al.
Publicado: (2019) -
DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice
por: Lian, Wenwen, et al.
Publicado: (2017) -
DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss
por: Zhou, Wei, et al.
Publicado: (2019) -
Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice
por: Lian, Wenwen, et al.
Publicado: (2017) -
Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR and Molecular Docking Approaches
por: Pang, Xiaocong, et al.
Publicado: (2017)