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Regulatory light chain phosphorylation augments length-dependent contraction in PTU-treated rats
Force production by actin–myosin cross-bridges in cardiac muscle is regulated by thin-filament proteins and sarcomere length (SL) throughout the heartbeat. Prior work has shown that myosin regulatory light chain (RLC), which binds to the neck of myosin heavy chain, increases cardiac contractility wh...
Autores principales: | Breithaupt, Jason J., Pulcastro, Hannah C., Awinda, Peter O., DeWitt, David C., Tanner, Bertrand C.W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314387/ https://www.ncbi.nlm.nih.gov/pubmed/30523115 http://dx.doi.org/10.1085/jgp.201812158 |
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