Cargando…

LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective

Inactivating mutations of the tumor suppressor gene Liver Kinase B1 (LKB1) are frequently detected in non-small-cell lung cancer (NSCLC) and cervical carcinoma. Moreover, LKB1 expression is epigenetically regulated in several tumor types. LKB1 has an established function in the control of cell metab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ciccarese, Francesco, Zulato, Elisabetta, Indraccolo, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874879/ https://www.ncbi.nlm.nih.gov/pubmed/31781355 http://dx.doi.org/10.1155/2019/8730816

Ejemplares similares

LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer
por: Bonanno, Laura, et al.
Publicado: (2019)

Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth
por: Zulato, Elisabetta, et al.
Publicado: (2018)

AMPK potentiation by LKB1 isoforms
por: Thibert, Chantal, et al.
Publicado: (2015)

LKB1 and AMPK and the cancer-metabolism link - ten years after
por: Hardie, D Grahame, et al.
Publicado: (2013)

Connecting LKB1 and AMPK links metabolism with cancer
por: Moore, Pete
Publicado: (2003)

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
por: Qu, Shuang, et al.
Publicado: (2022)

Arsenic Inhibits Neurite Outgrowth by Inhibiting the LKB1–AMPK Signaling Pathway
por: Wang, Xin, et al.
Publicado: (2010)

MLK3 Phophorylates AMPK Independently of LKB1
por: Luo, Lingyu, et al.
Publicado: (2015)

Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
por: Lo, Bryan, et al.
Publicado: (2012)

Liquiritin Attenuates Pathological Cardiac Hypertrophy by Activating the PKA/LKB1/AMPK Pathway
por: Aiyasiding, Xiahenazi, et al.
Publicado: (2022)

PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer
por: Kari, Suresh, et al.
Publicado: (2019)

Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation
por: Rho, Seung Bae, et al.
Publicado: (2021)

Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin
por: Zheng, Zhi, et al.
Publicado: (2012)

Kiss1 Inhibits the Proliferation of Nasopharyngeal Carcinoma Cells Via Activation of the LKB1/AMPK Pathway
por: Li, Tingting, et al.
Publicado: (2022)

LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK
por: Jeppesen, Jacob, et al.
Publicado: (2013)

LKB1 and AMPK differentially regulate pancreatic β-cell identity
por: Kone, Marina, et al.
Publicado: (2014)

LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells
por: Li, Nian-Shuang, et al.
Publicado: (2015)

Implementation of Next Generation Sequencing-Based Liquid Biopsy for Clinical Molecular Diagnostics in Non-Small Cell Lung Cancer (NSCLC) Patients
por: Zulato, Elisabetta, et al.
Publicado: (2021)

A subset of VEGFR‐TKIs activates AMPK in LKB1‐mutant lung cancer
por: Yang, Lujie, et al.
Publicado: (2022)

DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy
por: Wu, Ning, et al.
Publicado: (2023)

Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway
por: Dong, Guang-Zhi, et al.
Publicado: (2013)

Beneficial Effect of Taraxacum coreanum Nakai via the Activation of LKB1-AMPK Signaling Pathway on Obesity
por: Shin, Mi-Rae, et al.
Publicado: (2021)

Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC
por: Cheng, Fang-Ju, et al.
Publicado: (2020)

Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway
por: He, Yonghan, et al.
Publicado: (2013)

Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis
por: Chen, Yang, et al.
Publicado: (2022)

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated
por: Zhou, Wei, et al.
Publicado: (2014)

LKB1 and AMPK maintain epithelial cell polarity under energetic stress
por: Mirouse, Vincent, et al.
Publicado: (2007)

LKB1/AMPK and PKA Control ABCB11 Trafficking and Polarization in Hepatocytes
por: Homolya, László, et al.
Publicado: (2014)

LKB1 and AMPK maintain epithelial cell polarity under energetic stress
por: Mirouse, Vincent, et al.
Publicado: (2013)

LKB1 and AMPK instruct cone nuclear position to modify visual function
por: Burger, Courtney A., et al.
Publicado: (2021)

PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1
por: Mung, Kwan Long, et al.
Publicado: (2021)

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells
por: Endo, Hitoshi, et al.
Publicado: (2018)

STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact
por: Pons-Tostivint, Elvire, et al.
Publicado: (2021)

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways
por: Li, Yu-Cheng, et al.
Publicado: (2018)

Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
por: Bonanno, Laura, et al.
Publicado: (2022)

Cancer Metabolism and Resistance to Cell Death: Novel Therapeutic Perspectives
por: Ciccarese, Francesco
Publicado: (2022)

LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis
por: Li, Changzhi, et al.
Publicado: (2020)

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
por: Li, Nan, et al.
Publicado: (2019)

The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin
por: Shimada, Tatsuya, et al.
Publicado: (2022)

PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy
por: Zeng, Jin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0cege4jpo5102jv0u8t470uitc