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Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct
Notwithstanding the central biological role of the (6-4) photoadduct in the induction of skin cancer by sunlight, crucial mechanistic details about its formation have evaded characterization despite efforts spanning more than half a century. 4-Thiothymidine (4tT) has been widely used as an important...
Autores principales: | Ortiz-Rodríguez, Luis A., Reichardt, Christian, Hoehn, Sean J., Jockusch, Steffen, Crespo-Hernández, Carlos E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368040/ https://www.ncbi.nlm.nih.gov/pubmed/32680990 http://dx.doi.org/10.1038/s41467-020-17333-y |
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