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TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex
BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes. They have been proposed as therapeutic targets to diminish Wnt signaling output in intestinal malignancies. Here we find that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain...
Autores principales: | Zimmerli, Dario, Borrelli, Costanza, Jauregi-Miguel, Amaia, Söderholm, Simon, Brütsch, Salome, Doumpas, Nikolaos, Reichmuth, Jan, Murphy-Seiler, Fabienne, Aguet, MIchel, Basler, Konrad, Moor, Andreas E, Cantù, Claudio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434441/ https://www.ncbi.nlm.nih.gov/pubmed/32808927 http://dx.doi.org/10.7554/eLife.58123 |
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