Cargando…

Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases

Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme that catalyzes the addition of methyl groups to histone H3 at lysine 27, leading to gene silencing. Mutation or over-expression of EZH2 has been linked to many cancers including renal carcinoma. Recent studies have sho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Tingting, Yu, Chao, Zhuang, Shougang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930071/ https://www.ncbi.nlm.nih.gov/pubmed/33679454 http://dx.doi.org/10.3389/fphys.2021.640700

Ejemplares similares

Histone Methyltransferases as Therapeutic Targets for Kidney Diseases
por: Yu, Chao, et al.
Publicado: (2019)

Treatment of chronic kidney diseases with histone deacetylase inhibitors
por: Liu, Na, et al.
Publicado: (2015)

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
por: Zhou, Jie, et al.
Publicado: (2019)

Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer
por: Oki, Shinya, et al.
Publicado: (2017)

The histone methyltransferase Ezh2 restrains macrophage inflammatory responses
por: Kitchen, Gareth B., et al.
Publicado: (2021)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases
por: Zhou, Xun, et al.
Publicado: (2022)

The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets
por: Van Dessel, Nele, et al.
Publicado: (2010)

The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
por: Miele, Evelina, et al.
Publicado: (2017)

Multiple regulatory aspects of histone methyltransferase EZH2 in Pb-induced neurotoxicity
por: Xue, Wei-Zhen, et al.
Publicado: (2017)

New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis
por: Sheng, Lili, et al.
Publicado: (2020)

Epidermal Growth Factor Receptor: A Potential Therapeutic Target for Diabetic Kidney Disease
por: Sheng, Lili, et al.
Publicado: (2021)

The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice
por: Lee, Seul, et al.
Publicado: (2020)

Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer
por: Taniguchi, H, et al.
Publicado: (2012)

m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
por: Chen, Junchen, et al.
Publicado: (2019)

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
por: Karakashev, Sergey, et al.
Publicado: (2018)

Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish
por: Zhong, Yingbin, et al.
Publicado: (2018)

Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML
por: Kempf, Julia M., et al.
Publicado: (2021)

Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention
por: Tellez, Carmen S., et al.
Publicado: (2021)

Retraction: Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
por: Herrera-Merchan, A, et al.
Publicado: (2017)

Symphony of epigenetic and metabolic regulation—interaction between the histone methyltransferase EZH2 and metabolism of tumor
por: Zhang, Tengrui, et al.
Publicado: (2020)

Inhibition of histone methyltransferase EZH2 ameliorates early acute renal allograft rejection in rats
por: Li, Long, et al.
Publicado: (2016)

New epigenetic pathway for stemness maintenance mediated by the histone methyltransferase Ezh1
por: Hidalgo, Isabel, et al.
Publicado: (2013)

Non-coding RNAs as potential biomarkers and therapeutic targets in polycystic kidney disease
por: Zheng, Qi, et al.
Publicado: (2022)

Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids
por: Mola, Silvia, et al.
Publicado: (2021)

Histone Modifications in Acute Kidney Injury
por: Wang, Jun, et al.
Publicado: (2022)

Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage
por: Caruso, Lisa B., et al.
Publicado: (2018)

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
por: Curry, Edward, et al.
Publicado: (2015)

Weaver Syndrome‐Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro
por: Cohen, Ana S.A., et al.
Publicado: (2016)

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
por: Papakonstantinou, Nikos, et al.
Publicado: (2016)

Neuronal Histone Methyltransferase EZH2 Regulates Neuronal Morphogenesis, Synaptic Plasticity, and Cognitive Behavior in Mice
por: Zhang, Mei, et al.
Publicado: (2023)

Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo
por: Kuang, Yan, et al.
Publicado: (2017)

EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer
por: Chen, Jianfeng, et al.
Publicado: (2023)

The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection
por: Chen, Xiangyu, et al.
Publicado: (2019)

Protein arginine methyltransferases in renal development, injury, repair, and fibrosis
por: Yu, Jianjun, et al.
Publicado: (2023)

Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury
por: Zhang, Chunyun, et al.
Publicado: (2022)

Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI
por: Li, Bojun, et al.
Publicado: (2023)

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation
por: Kojima, Machiko, et al.
Publicado: (2019)

Neighborhood matters: Response to EZH2 methyltransferase inhibitors
por: Gharpure, Kshipra M, et al.
Publicado: (2013)

EZH2 Methyltransferase Regulates Neuroinflammation and Neuropathic Pain
por: Weng, Han-Rong, et al.
Publicado: (2023)

EZH2 Expression in Retinoblastoma: A Potential Therapeutic Target
por: Lin, Zhuangling, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_75ej5sfcrui35ge3f4je32ar14