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Parameters and determinants of responses to selection in antibody libraries
The sequences of antibodies from a given repertoire are highly diverse at few sites located on the surface of a genome-encoded larger scaffold. The scaffold is often considered to play a lesser role than highly diverse, non-genome-encoded sites in controlling binding affinity and specificity. To gau...
Autores principales: | Schulz, Steven, Boyer, Sébastien, Smerlak, Matteo, Cocco, Simona, Monasson, Rémi, Nizak, Clément, Rivoire, Olivier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993935/ https://www.ncbi.nlm.nih.gov/pubmed/33765014 http://dx.doi.org/10.1371/journal.pcbi.1008751 |
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