Cargando…
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase
O-GlcNAc is an essential and dynamic post-translational modification presented on thousands of nucleocytoplasmic proteins. Interrogating the role of O-GlcNAc on a single target protein is crucial yet challenging to perform in cells. Herein, we developed a nanobody-fused split O-GlcNAcase (OGA) as an...
Autores principales: | Ge, Yun, Ramirez, Daniel H., Yang, Bo, D’Souza, Alexandria K., Aonbangkhen, Chanat, Wong, Stephanie, Woo, Christina M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085020/ https://www.ncbi.nlm.nih.gov/pubmed/33686291 http://dx.doi.org/10.1038/s41589-021-00757-y |
Ejemplares similares
-
Structural and functional insight into human O-GlcNAcase
por: Roth, Christian, et al.
Publicado: (2017) -
O-GlcNAcase contributes to cognitive function in Drosophila
por: Muha, Villo, et al.
Publicado: (2020) -
Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation
por: Yu, Yang, et al.
Publicado: (2012) -
Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition
por: Schimpl, Marianne, et al.
Publicado: (2012) -
O-GlcNAcase Expression is Sensitive to Changes in O-GlcNAc Homeostasis
por: Zhang, Zhen, et al.
Publicado: (2014)