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Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells
Metastasis and chemoresistance in colorectal cancer are mediated by certain poorly differentiated cancer cells, known as cancer stem cells, that are maintained by Notch downstream signaling initiated upon Notch cleavage by the metalloprotease ADAM10. It has been shown that ADAM10 overexpression corr...
Autores principales: | Saha, Nayanendu, Baek, Du-San, Mendoza, Rachelle P., Robev, Dorothea, Xu, Yan, Goldgur, Yehuda, De La Cruz, M. Jason, de Stanchina, Elisa, Janes, Peter W., Xu, Kai, Dimitrov, Dimiter S., Nikolov, Dimitar B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499537/ https://www.ncbi.nlm.nih.gov/pubmed/36917886 http://dx.doi.org/10.1016/j.biopha.2023.114494 |
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