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DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining
Clustered lesions are defined as ≥two lesions within 20 bps and are generated in DNA by ionizing radiation. In vitro studies and work in bacteria have shown that attempted repair of two closely opposed lesions can result in the formation of double strand breaks (DSBs). Since mammalian cells can repa...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528178/ https://www.ncbi.nlm.nih.gov/pubmed/18653525 http://dx.doi.org/10.1093/nar/gkn450 |