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Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system
Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone protei...
Autores principales: | McKinnon, Chris, Goold, Rob, Andre, Ralph, Devoy, Anny, Ortega, Zaira, Moonga, Julie, Linehan, Jacqueline M., Brandner, Sebastian, Lucas, José J., Collinge, John, Tabrizi, Sarah J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752964/ https://www.ncbi.nlm.nih.gov/pubmed/26646779 http://dx.doi.org/10.1007/s00401-015-1508-y |
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