Cargando…
Structures of human mitofusin 1 provide insight into mitochondrial tethering
Mitochondria undergo fusion and fission. The merging of outer mitochondrial membranes requires mitofusin (MFN), a dynamin-like GTPase. How exactly MFN mediates membrane fusion is poorly understood. Here, we determined crystal structures of a minimal GTPase domain (MGD) of human MFN1, including the p...
Autores principales: | Qi, Yuanbo, Yan, Liming, Yu, Caiting, Guo, Xiangyang, Zhou, Xin, Hu, Xiaoyu, Huang, Xiaofang, Rao, Zihe, Lou, Zhiyong, Hu, Junjie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147005/ https://www.ncbi.nlm.nih.gov/pubmed/27920125 http://dx.doi.org/10.1083/jcb.201609019 |
Ejemplares similares
-
Structural insights into G domain dimerization and pathogenic mutation of OPA1
por: Yu, Caiting, et al.
Publicado: (2020) -
Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin
por: Huang, Xiaofang, et al.
Publicado: (2017) -
Mitochondrial fusion: Reaching the end of mitofusin’s tether
por: Formosa, Luke E., et al.
Publicado: (2016) -
Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1
por: Yan, Liming, et al.
Publicado: (2020) -
Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion
por: Yan, Liming, et al.
Publicado: (2015)