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TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects. Of the STAT-mediated signal transduction pathways, STAT3 transcriptional control is b...
Autores principales: | Mori, Raffaele, Wauman, Joris, Icardi, Laura, Van der Heyden, José, De Cauwer, Lode, Peelman, Frank, De Bosscher, Karolien, Tavernier, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698428/ https://www.ncbi.nlm.nih.gov/pubmed/29162862 http://dx.doi.org/10.1038/s41598-017-15912-6 |
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