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TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling
TNF is not only a major effector molecule of PAMP/DAMP-activated macrophages, but also regulates macrophage function and viability. We recently demonstrated that TNFR2 triggers necroptosis in macrophages with compromised caspase activity by two cooperating mechanisms: induction of endogenous TNF wit...
Autores principales: | Siegmund, Daniela, Ehrenschwender, Martin, Wajant, Harald |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134143/ https://www.ncbi.nlm.nih.gov/pubmed/30206205 http://dx.doi.org/10.1038/s41419-018-0973-3 |
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