Cargando…

Fluorofenidone affects hepatic stellate cell activation in hepatic fibrosis by targeting the TGF-β1/Smad and MAPK signaling pathways

The aim of the present research was to study the therapeutic impacts of fluorofenidone (AKF-PD) on pig serum (PS)-induced liver fibrosis in rats and the complex molecular mechanisms of its effects on hepatic stellate cells (HSCs). Wistar rats were randomly divided into normal control, PS and PS/AKF-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Yu, Li, Li, Zhang, Xin, Xie, Mingyan, Yang, Congying, Tu, Sha, Shen, Hong, Hu, Gaoyun, Tao, Lijian, Yang, Huixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566051/ https://www.ncbi.nlm.nih.gov/pubmed/31258636 http://dx.doi.org/10.3892/etm.2019.7548

Ejemplares similares

Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer
por: Peng, Xiongqun, et al.
Publicado: (2023)

A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis
por: Chen, Haihua, et al.
Publicado: (2019)

Correction to: A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis
por: Chen, Haihua, et al.
Publicado: (2020)

Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway
por: Lv, Xin, et al.
Publicado: (2021)

Smad7-overexpressing rat BMSCs inhibit the fibrosis of hepatic stellate cells by regulating the TGF-β1/Smad signaling pathway
por: Wu, Shi-Pin, et al.
Publicado: (2017)

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway
por: Zhou, Ling, et al.
Publicado: (2017)

Effect of Exogenous Fetuin-A on TGF-β/Smad Signaling in Hepatic Stellate Cells
por: Zhou, Yulai, et al.
Publicado: (2016)

Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage
por: Liao, Xiaohua, et al.
Publicado: (2022)

Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis
por: Yang, Yang, et al.
Publicado: (2021)

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
por: Mu, Mao, et al.
Publicado: (2018)

Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway
por: Dai, Qin, et al.
Publicado: (2020)

Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways
por: Xiong, Xuan, et al.
Publicado: (2014)

Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology
por: Jiang, Feiya, et al.
Publicado: (2021)

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]
por: Mu, Mao, et al.
Publicado: (2019)

Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway
por: Zou, Gao-Liang, et al.
Publicado: (2019)

Activation of primary hepatic stellate cells and liver fibrosis induced by targeting TGF-β1/Smad signaling in schistosomiasis in mice
por: Huang, Ping, et al.
Publicado: (2022)

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways
por: Wu, Liwei, et al.
Publicado: (2017)

Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL‐1β/IL‐1R1/MyD88/NF‐κB pathway
por: Song, Cheng, et al.
Publicado: (2016)

Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2
por: Tee, Jie Kai, et al.
Publicado: (2018)

Suaeda glauca Attenuates Liver Fibrosis in Mice by Inhibiting TGFβ1-Smad2/3 Signaling in Hepatic Stellate Cells
por: Hong, You-Jung, et al.
Publicado: (2023)

Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway
por: Seo, Hye-Young, et al.
Publicado: (2019)

Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro
por: Wang, Shiwei, et al.
Publicado: (2023)

Trimetazidine inhibits liver fibrosis and hepatic stellate cell proliferation and blocks transforming growth factor-β (TGFβ)/Smad signaling in vitro and in vivo
por: Ding, Wenwen, et al.
Publicado: (2022)

Probiotics counteract the expression of hepatic profibrotic genes via the attenuation of TGF-β/SMAD signaling and autophagy in hepatic stellate cells
por: Kanmani, Paulraj, et al.
Publicado: (2022)

Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1/Smad Signaling Pathway
por: Yuan, Xingxing, et al.
Publicado: (2018)

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells
por: Zhong, Xiaolin, et al.
Publicado: (2020)

Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway
por: Song, Li-Ying, et al.
Publicado: (2019)

Differential Regulation of TGF-β/Smad Signaling in Hepatic Stellate Cells between Acute and Chronic Liver Injuries
por: Yoshida, Katsunori, et al.
Publicado: (2012)

Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis
por: Yang, Hui, et al.
Publicado: (2019)

Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells
por: Zhang, Jinhang, et al.
Publicado: (2020)

Phenylethanol Glycosides from Cistanche tubulosa Suppress Hepatic Stellate Cell Activation and Block the Conduction of Signaling Pathways in TGF-β(1)/smad as Potential Anti-Hepatic Fibrosis Agents
por: You, Shu-Ping, et al.
Publicado: (2016)

Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling
por: Li, Jun, et al.
Publicado: (2019)

Fluorofenidone Inhibits the Proliferation of Lung Adenocarcinoma Cells
por: Deng, Zheng-hao, et al.
Publicado: (2017)

Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways
por: Ji, Jie, et al.
Publicado: (2021)

Bevacizumab Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells
por: Huang, Yangqing, et al.
Publicado: (2013)

Neoagarooligosaccharide Protects against Hepatic Fibrosis via Inhibition of TGF-β/Smad Signaling Pathway
por: Yang, Ji Hye, et al.
Publicado: (2021)

Glycyrrhetinic Acid-Induced MiR-663a Alleviates Hepatic Stellate Cell Activation by Attenuating the TGF-β/Smad Signaling Pathway
por: Guo, Xin-Xin, et al.
Publicado: (2020)

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis
por: Schon, Hans-Theo, et al.
Publicado: (2016)

MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7
por: Zhou, Qian-Yang, et al.
Publicado: (2021)

Fluorofenidone attenuates paraquat-induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy
por: Jiang, Feiya, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6orhinsha6okdqublo2semetgo