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Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice

BACKGROUND: To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice constitutively expressing the mPGES1 (Ptges) humanized allele. METHODS: Series...

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Detalles Bibliográficos
Autores principales:	Gurusamy, Malarvizhi, Nasseri, Saeed, Rampa, Dileep Reddy, Feng, Huiying, Lee, Dongwon, Pekcec, Anton, Doods, Henri, Wu, Dongmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351447/ https://www.ncbi.nlm.nih.gov/pubmed/34372885 http://dx.doi.org/10.1186/s12967-021-03016-9

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