Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth

Cholesterol and fatty acids are essential lipids that are critical for membrane biosynthesis and fetal organ development. Cholesteryl esters (CE) are degraded by hormone-sensitive lipase (HSL) in the cytosol and by lysosomal acid lipase (LAL) in the lysosome. Impaired LAL or HSL activity causes rare...

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Detalles Bibliográficos
Autores principales: Kuentzel, Katharina B., Bradić, Ivan, Akhmetshina, Alena, Korbelius, Melanie, Rainer, Silvia, Kolb, Dagmar, Gauster, Martin, Vujić, Nemanja, Kratky, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508985/
https://www.ncbi.nlm.nih.gov/pubmed/34638755
http://dx.doi.org/10.3390/ijms221910416

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