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Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth
Cholesterol and fatty acids are essential lipids that are critical for membrane biosynthesis and fetal organ development. Cholesteryl esters (CE) are degraded by hormone-sensitive lipase (HSL) in the cytosol and by lysosomal acid lipase (LAL) in the lysosome. Impaired LAL or HSL activity causes rare...
Autores principales: | Kuentzel, Katharina B., Bradić, Ivan, Akhmetshina, Alena, Korbelius, Melanie, Rainer, Silvia, Kolb, Dagmar, Gauster, Martin, Vujić, Nemanja, Kratky, Dagmar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508985/ https://www.ncbi.nlm.nih.gov/pubmed/34638755 http://dx.doi.org/10.3390/ijms221910416 |
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