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An allosteric HTRA1-calpain 2 complex with restricted activation profile
Zymogen activation is a widely conserved regulatory principle across protease clans. It describes the irreversible activation by processing of the inactive zymogen precursor by an active protease. Here we report an alternative and reversible mechanism of protease activation, where the activator is a...
Autores principales: | Rey, Juliana, Breiden, Maike, Lux, Vanda, Bluemke, Anika, Steindel, Maike, Ripkens, Kamilla, Möllers, Bastian, Bravo Rodriguez, Kenny, Boisguerin, Prisca, Volkmer, Rudolf, Mieres-Perez, Joel, Clausen, Tim, Sanchez-Garcia, Elsa, Ehrmann, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168489/ https://www.ncbi.nlm.nih.gov/pubmed/35349341 http://dx.doi.org/10.1073/pnas.2113520119 |
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