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Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy
Myotonic dystrophy (DM) is caused by expansions of C(C)TG repeats in the non-coding regions of the DMPK and CNBP genes, and DM patients often suffer from sudden cardiac death due to lethal conduction block or arrhythmia. Specific molecular changes that underlie DM cardiac pathology have been linked...
Autores principales: | Lee, Kuang-Yung, Seah, Carol, Li, Ching, Chen, Yu-Fu, Chen, Chwen-Yu, Wu, Ching-I, Liao, Po-Cheng, Shyu, Yu-Chiau, Olafson, Hailey R, McKee, Kendra K, Wang, Eric T, Yeh, Chi-Hsiao, Wang, Chao-Hung |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476621/ https://www.ncbi.nlm.nih.gov/pubmed/35567413 http://dx.doi.org/10.1093/hmg/ddac108 |
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