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Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

Precise control of protein degradation is critical for life, yet how natural genetic variation affects this essential process is largely unknown. Here, we developed a statistically powerful mapping approach to characterize how genetic variation affects protein degradation by the ubiquitin-proteasome...

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Detalles Bibliográficos
Autores principales:	Collins, Mahlon A, Mekonnen, Gemechu, Albert, Frank Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634822/ https://www.ncbi.nlm.nih.gov/pubmed/36218234 http://dx.doi.org/10.7554/eLife.79570

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